5.13 Leukotriene Receptor Antagonists

Montelukast is a leukotriene antagonist medication with a distinctly-shaped square tablet. See Figure 5.19.^[1]

Mechanism of Action: Montelukast blocks leukotriene receptors and decreases inflammation.

Indications: Montelukast is used for the long-term control of asthma and for decreasing the frequency of asthma attacks. It is also indicated for exercise-induced bronchospasm and allergic rhinitis.

Nursing Considerations: The medication is safe for children 12 months and older. It is available in granule packets and chewable tablets, as well as regular tablets.

Boxed Warning: Serious mental health side effects, including suicidal ideation. Should be avoided for treating mild asthma unless conventional treatment is ineffective.

Side Effects/Adverse Effects: Montelukast can cause headache, cough, nasal congestion, nausea, hepatotoxicity, and suicidal ideation.

Health Teaching & Health Promotion: Clients should be instructed to take medications at the same time each day and at least two hours prior to exercise. They should not discontinue medications without notifying the health care provider.^[2]

Now let’s take a closer look at the medication grid on montelukast in Table 5.13.^{[3],[4],[5],[6]}

Table 5.13 Montelukast Medication Grid