5.10 Beta-2 Agonists

Albuterol is an example of a short-acting Beta-2 agonist. See Figures 5.11^[1], 5.12^[2] and 5.13 ^[3]for images of an albuterol inhaler, ampule, and nebulizer.

Salmeterol is an example of a long-acting Beta-2 agonist.

See the “Autonomic Nervous System” chapter for more information regarding Beta-2 agonists.

Mechanism of Action: Albuterol and salmeterol stimulate Beta 2-adrenergic receptors in the smooth muscle of bronchi and bronchioles producing bronchodilation. Beta-1 receptors can also be inadvertently stimulated, causing tachycardia.

Indications: Short-acting albuterol is used to prevent or treat bronchospasms in people with asthma, reversible obstructive airway disease, or exercise-induced bronchospasm. Long-acting salmeterol is used to prevent bronchospasm.

Nursing Considerations: Nurses should monitor respiratory rate, oxygen saturation, and lung sounds before and after administration.

Side Effects/Adverse Effects: Beta-2 agonists can cause muscle tremor, excessive cardiac stimulation, and CNS stimulation.^[4]

Health Teaching & Health Promotion: Clients should be instructed to take medication as directed and report any sustained or worsening symptoms to their health care provider. When first using an inhaler, clients should be instructed to prime the inhaler unit prior to administering their medication. Use of medications like albuterol can cause an unusual taste in the mouth, and rinsing the mouth with water after use is permitted. Clients should have an understanding of medication onset and use short-acting and long-acting inhalers appropriately.^[5]

Now let’s take a closer look at the medication grid for albuterol and salmeterol in Table 5.10.^{[6],[7],[8],[9],[10]}

Table 5.10 Albuterol and Salmeterol Medication Grid