Introduction to Reconstitution
Vocabulary
Normal Saline (NS) – A sterile solution containing 0.9% sodium chloride (salt) in water
Sterile Water (SW) – A purified liquid used for reconstitution
Vial – The container holding the powdered medication
Concentration or Final Concentration – The strength of the reconstituted solution, often expressed in milligrams per milliliter (mg/mL)
Dilution – Adding additional liquid (usually normal saline) to achieve the desired concentration
Intramuscular (IM) – The route of medication administration where the drug is injected directly into a muscle
Reconstitution Conversions
Reconstituting medication is a common task for nurses when dealing with powdered or concentrated forms of drugs. Reconstitution is necessary when a medication is in a powdered form and needs to be mixed with a specific amount of liquid (usually sterile water or saline) to create a usable solution.
1. Determine What Information is Needed From Problem.
You need to know:
-
- Order
- Final concentration
2. Dimensional Analysis Review
Using dimensional analysis, you will be able to solve the following problem, where you will be determining how many mL you will give the patient.
Rule 1. Set up the problem. What units will your answer have?
[latex]\frac{unit}{1} -or- \frac{unit}{unit}[/latex]
Rule 2. Work the problem until the unit(s) on one side match the units on the other.
Rule 3. Do your units MATCH?
Rule 4. Solve by multiplying all the top numbers and write the answer in the numerator, and then multiply all the bottom numbers and write the answer in the denominator.
[latex]\dfrac{numerator}{denominator}[/latex] = Dive the top by the bottom
Rule 5. Write the number to four (4) decimals and then round and write your units appropriately.
3. Conversion Steps
Reconstitution Example
Order: 300 mg IM of a drug
Available: 1000 mg vial with directions to add 4.6 mL SW for injection for a final concentration of 200 mg/mL
How many mL will you administer? (Round to the nearest tenth)
mL → [latex]\frac{1mL}{200mg} x 300mg = 1.5mL[/latex]
Reconstitution Conversions Video Tutorial[1]
- WisTech Open. (2024, August 12). Nursing Dosage Calculations - Reconstitution. [Video]. YouTube. CC BY 4.0. https://www.youtube.com/watch?v=85j5dHyOsMU ↵
A sterile solution containing 0.9% sodium chloride (salt) in water.
A purified liquid used for reconstitution.
The container holding the powdered medication.
The strength of the reconstituted solution, often expressed in milligrams per milliliter (mg/mL).
Adding additional liquid (usually normal saline) to achieve the desired concentration.
Injected deep into a muscle.